Biomarker Kinetics ™ : CA-125 KELIM ™ Calculator in Ovarian Cancer & Other Biomarkers

Changes in serum tumor biomarkers may indicate treatment efficacy. Mathematical modeling allows calculation of the equations describing the longitudinal tumor biomarker time-changes. The model-based population kinetic approach is particularly relevant as it enables determination of individual kinetic profiles parameters based on a few timepoints, with limited impact of inter- and intra-individual variability of timepoints and assays.

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The Team

The models were developed by Team 3 of EA3738 CICLY of Lyon University (Université Claude Bernard Lyon 1, France) and Lyon University Hospital (Hospices Civils de Lyon, France), in collaboration with the collaborative French GINECO Group, under the supervision of Prof Benoit You MD PhD. The internet site and the smartphone application were developed with the support of HCL Fondation. Translation in Mandarin langage: The Biomarker.Kinetics team would like to thank the Dr Weiwei Feng team (Ruijin Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China) who translated the English content in Mandarin langage.

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Université Claude Bernard Lyon 1 HCL Fondation HCL

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News

SALVOVAR phase III trial: Activated in France and Japan => Already 5 patients enrolled !
2024-08-23

SALVOVAR phase III trial: Activated in France and Japan => Already 5 patients enrolled !

SALVOVAR is a phase III trial meant to show that densification of the chemotherapy with the weekly dose-dense paclitaxel in patients presenting with an unfavorable KELIM score < 1.0 and a disease not amenable to complete interval debulking surgery could improve their prognosis. For more details : https://salvovar-cms-uploads.s3.fr-par.scw.cloud/e2898237-e03b-4554-85e8-a2440af3e56d.mp4

Meeting for SALVOVAR project at ESMO 2023
2023-10-20

Meeting for SALVOVAR project at ESMO 2023

The partners, investigators and investigating groups of SALVOVAR project are invited to join for a face to face meeting at Madrid on October 20th 2023 at 12:00 am for partners and 2 pm for investigators Site: Novotel Madrid Campo de las Naciones (Hotel Novotel Madrid Campo de las Naciones) - Campo De Las Naciones, C. de Ámsterdam, N° 3, 28042 Madrid, Spain Just facing the convention center

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Salvovar logo

Learn more about the future European clinical phase III trial SALVOVAR, where the patients with unfavorable KELIM score < 1.0 and a disease not amenable to complete interval debulking surgery after 3 to 4 cycles standard neo-adjuvant chemotherapy will be randomized to the continuation of the standard 3-weekly regimen, or a salvage regimen with weekly dose-dense carboplatin-paclitaxel

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